The importance of subtelomeric chromosome rearrangements has been clearly shown by their observed association with unexplained mental retardation and congenital abnormalities.

Individual subtelomere specific probes have been used to focus on particular subtelomeric regions and have resulted in the establishment of new syndromes as the chromosome 1p36 deletion syndrome and the 22q13.3 deletion syndrome. The probes are also finding applications in the investigation of autistic disorders, recurrent miscarriages and haematological malignancies.

Cytocell offers a complete set of liquid subtelomere specific probes identifying 41 of the 46 human subtelomeres with the exclusion of the p-arm telomeres of the acrocentric chromosomes. The probes are available independently and directly labelled in either a red or a green fluorophore (Texas Red or FITC spectra respectively).